Kenedy
Brazilian Kenedy was brought in by Rafa Benitez in the January transfer window to add an exciting attacking option for the second half of the season.
The 22-year-old boasts a turn of pace when one-on-one as well as trickery and skill when in possession.
He is likely to play on the left-wing on Saturday, and will need to be closely watched by Southampton right-back Cedric.
In such an important game at the bottom of the Premier League, Kenedy could just provide the attacking penetration that Newcastle need to gain a vital win.