Heavy schedule for Arsenal
Arsenal’s participation in the Europa League has seen them faced with two Round of 32 games against Bate Borisov before they meet Saints.
A 1-0 loss in Belarus last Thursday also means that a number of their big players may start in the second-leg this week.
Gunners boss Unai Emery has two options in going for Champions League qualification via the league or by winning the Europa League.
If he decides that the latter will be prioritised, Saints could face a rotated side on Sunday with a further league game for both side to think about in midweek.