Southampton head to the London stadium in relatively carefree fashion, after securing safety with their thrilling 3-3 draw against Bournemouth last week.
With injuries to several players, including defensive duo Maya Yoshida and Jannik Vestergaard, Saints boss Ralph Hasenhuttl might be tempted to experiment with his starting line up.
It is possible that Ryan Bertrand might join Bednarek and Stephens in a back three, whilst Targett might benefit from a recall following his goal scoring heroics from the bench.
Both teams have little to play for and with the summer holidays looming, it has the potential to be snore draw.
Nevertheless, West Ham have some exciting players and here are three of the main threats from the West Ham side: