Southampton have claimed three draws and one win against Brighton in Premier League meetings.
This time around, Ralph Hasenhuttl’s side will be looking to get their first points of the season on the board.
They will be looking to do so against Graham Potter’s Seagulls, who have enjoyed an impressive start to the campaign.
Both sides have some talented players though and it will be an intriguing match-up. Will either side come out on top?
Here are three key areas that will decide the game at the AMEX Stadium: