Arsenal line-up
Bernd Leno; Ainsley Maitland-Niles, Rob Holding/David Luiz, Gabriel, Kieran Tierney; Dani Ceballos, Mohamed Elneny; Nicolas Pepe, Bukayo Saka, Alexandre Lacazette; Pierre-Emerick Aubameyang
Gunners boss Mikel Arteta has a number of players waiting to prove their fitness and an important duo out through suspension.
Nicolas Pepe will return from suspension, whilst David Luiz, Reiss Nelson and Sead Kolasinac could return to contention after injuries.
Granit Xhaka and Hector Bellerin both have suspensions ahead of facing Saints. Thomas Partey and Gabriel Martinelli are longer-term absentees.