Tonda Eckert is unlikely to deviate too much for the side that has won three games on the trot. Only Ryan Fraser is unavailable from the squad that travelled to Charlton Athletic on Saturday.
Elias Jelert, Mads Roerslev and Shea Charles are all still injured. Oriol Romeu is still developing his fitness ahead of joining the squad in the coming weeks.
Southampton predicted lineup: (3-4-3)
Goalkeeper and Defenders
Goalkeeper - Gavin Bazunu: Bazunu is integral to the way that Southampton are playing out from the back. Against Charlton, the three centre-backs were able to trust the keeper with the ball and start meaningful attacks from the back. Still, Bazunu could be criticised for his inability to dominate his six-yard box on crosses. He was caught flat-footed for Charlton's goal.
Centre-Back - Taylor Harwood-Bellis: Harwood-Bellis continued his good form at Charlton with a well-rounded performance. He is starting to thread passes through to midfield and advancing with the ball. His defending has been solid and he will start against Leicester on Tuesday.
Centre-Back - Nathan Wood: Wood will start against Leicester City but there are issues emerging that Eckert might want to address with the player. In possession, he can be a little slow to move the ball on and he puts himself under too much pressure because of that.
Centre-Back - Jack Stephens: Stephens controlled the tempo as Southampton saw out the match at Leicester City. The captain is playing well and regaining the faith of the fans who had slaughtered him at the start of the season.
Midfielders
Right Midfield - Tom Fellows: Assuming that he is fit, Tom Fellows will continue in the hybrid wing-back role. Just as he did at Sheffield Wednesday, dribbling inside and passing for Finn Azaz to score, he did the same at Charlton on Saturday for Manning's opener. He could pose Leicester City similar problems.
Centre Midfield - Cameron Bragg: Bragg could make his home debut on Tuesday after a brilliant performance at Charlton on Saturday. Flynn Downes will be on standby should the manager decide that his experience is needed against Harry Winks and Oliver Skipp.
Centre Midfield - Caspar Jander: Jander followed up his goal against Sheffield Wednesday with another at Charlton on Saturday. The 22-year-old German midfielder is adding goals to his brilliant all-round game and he is becoming one of Southampton's most consistent players. Having Bragg or Downes next to him in midfield is giving Jander the insurance he needs to make attacking runs.
Left Midfield - Welington: Eckert could make just one change for the visit of Leicester to St Mary's. The threat of Abdul Fatawu could tempt the interim boss to switch out Ryan Manning in favour of Welington. The Brazilian is a better defender than Manning and he has more pace. These are the attributes that may give Welington the nod in a tight call.
Forwards
Left Forward - Léo Scienza: Another brilliant display of attacking intent at Charlton on Saturday put Southampton on the front foot from the first couple of minutes. Scienza's direct dribbling at pace has caused defences problems all season and these runs are now turning into goals and assists. Withdrawn after 60 minutes at Charlton, Scienza will be fresh and ready to go against the Foxes on Tuesday.
Centre Forward - Adam Armstrong: Arguably Southampton's best player against Charlton, Armstrong will be very keen to build on his goal and two assists.
Right Forward - Finn Azaz: Three goals in two matches, sandwiched by the international break, is the return that Southampton might have expected when they paid an initial fee of £12 million for the Republic of Ireland international in the summer. If Azaz had made the most of an early gift from Léo Scienza, he might have gone home from Charlton on Saturday with the match ball under his arm.